Day 4: Analyzing Some Results

Today we completed a third day of stability tests at Integrated Lab Solutions. So far, we had done a standard test (same day analyzing), one after 24 hours, and today we set up the test for 48 hours (after the sample was taken). Additionally the past two days we had messed around with the pH of samples so that they could continue the stability tests in different environments in the future. But today, after we (Ben, Chief Scientist, and I) set up the day 3 trial of the long term stability test, we got to take a look at some of the results that they got yesterday afternoon from the 24 hour trial. One of the other lab technicians had spent the morning reviewing and finalizing the results so that we could compare them to the results from day 1. While looking at the two sets of data, we noticed an increase in detected concentration of almost all of the drugs from day 1 to day 2. Only a few had decreased and when they did decrease it was much less significant than those that increased. Noticing this pattern, we made a joint spreadsheet with both sets of data and programmed the spreadsheet with equations to tell us the % difference from day 1 to day 2. Some of the detected concentrations increased by as much as 50%! Unfortunately, even though I got to program the LCMS-MS to read out day 3 samples, the results were not available by the time that I left ILS. Luckily, Ben said that he would send me the final results of the study when the data was retrieved with a discussion of all of the results. I look forward to hearing about the end of this experiment, and enjoyed my time at Integrated Lab Solutions.

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